EXOGENOUS LUNG SURFACTANT (NAT) FOR THE TREATMENT OF SEVERE HYALINE MEMBRANE DISEASE (HMD) INITIAL CLINICAL EXPERIENCE
نویسندگان
چکیده
منابع مشابه
Randomized controlled trial of exogenous surfactant for the treatment of hyaline membrane disease.
We conducted a prospective, randomized, unblinded, controlled trial of exogenous bovine surfactant (surfactant TA) in premature infants requiring ventilator support for the treatment of severe hyaline membrane disease. Forty-one low birth weight infants with severe hyaline membrane disease were randomly assigned to saline or surfactant therapy and treated within eight hours of birth. Significan...
متن کاملHyaline membrane disease (HMD): the role of the perinatal pathologist
Hyaline membrane disease (HMD), the pathologic correlate of respiratory distress syndrome (RDS) of the newborn, is an acute lung disease of premature infant caused by inadequate amounts of surfactant. Decreased surfactant results in insufficient surface tension in the alveolus during expiration, leading to atelectasis, decreased gas exchange, severe hypoxia and acidosis. HMD predominantly occur...
متن کاملArtificial surfactant therapy for hyaline membrane disease
The demonstration that the lungs of infants who died with hyaline membrane disease (HMD) had abnormal surface properties' prompted a number of attempts to treat the condition by administration of material with surface tension-lowering properties. The substance mainly used for this purpose during the period 1964-7 was synthetic dipalmitoyllecithin (DPL) prepared as an aerosol either in a mixture...
متن کاملAnother approach to assisted ventilation in the treatment of hyaline membrane disease (HMD).
Authors’ address: Howard S. Gruber and Marshall H. Klaus, Case Western Reserve School of Medicine, Department of Pediatrics, Cleveland, O. (USA) Thirty-six infants (mean birthweight 1709 g) with severe HMD were treated with intermittent mask and bag ventilation as an alternative to the mechanical respirator. Previous therapy with oxygen, NaHCO7⁄8, glucose infusion and thermoregulation was judge...
متن کاملArtificial surfactant therapy in hyaline-membrane disease.
Ten preterm infants severely ill with hyaline-membrane disease (HMD) were given artificial surfactant endotracheally. Oxygenation and alveolar-arterial oxygen gradients improved, the levels of inspired oxygen and peak respirator pressure could be reduced, and many of the radiological abnormalities resolved. Acidosis and systemic hypotension were also reversed. In nine infants a patent ductus ar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 1992
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199212000-00041